Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 2/20 | 0.76 |
| ▸ | DNASE1L3 | Q13609 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29543257 | 1.00 | SOS1 (0.76) | SOS1DNASE1L3PRMT1USP2L3MBTL1 | |
| SCHEMBL29544864 | 0.91 | SOS1 (0.76) | SOS1DNASE1L3PRMT1USP2L3MBTL1 | |
| SCHEMBL13180156 | 0.91 | SOS1 (0.76) | SOS1DNASE1L3PRMT1USP2L3MBTL1 | |
| SCHEMBL15277723 | 0.88 | SOS1 (0.67) | SOS1USP2L3MBTL1MEN1POLB | |
| SCHEMBL10059473 | 0.86 | SOS1 (1.00) | SOS1DNASE1L3PRMT1USP2L3MBTL1 | |
| SCHEMBL17254331 | 0.81 | SOS1 (0.62) | SOS1DNASE1L3PRMT1USP2L3MBTL1 | |
| SCHEMBL13015010 | 0.81 | SOS1 (0.74) | SOS1DNASE1L3PRMT1USP2L3MBTL1 | |
| SCHEMBL2737206 | 0.81 | SOS1 (0.85) | SOS1DNASE1L3PRMT1USP2L3MBTL1 | |
| SCHEMBL19335118 | 0.79 | SOS1 (0.61) | SOS1DNASE1L3PRMT1USP2L3MBTL1 | |
| SCHEMBL13180155 | 0.77 | SOS1 (0.61) | SOS1DNASE1L3PRMT1USP2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9549988-B2 | Pharmaceutical compounds targeted by MIF affinity-tethered moieties | RJS Biologics (US) | 2017-01-24 | — | — | US | disclosed |
| US-20150352217-A1 | Pharmaceutical Compounds Targeted by MIF Affinity-Tethered Moieties | RJS BIOLOGICS LLC | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150352217-A1 | Pharmaceutical Compounds Targeted by MIF Affinity-Tethered Moieties | MIF, HMGB2, HMGB1 | SOS1 3636/4885DNASE1L3 420/4885PRMT1 3822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.