SCHEMBL173151

SCHEMBL173151

Nc1ncnc2c1ncn2[C@@H]1O[C@H](CN2CC2)C(O)C1O

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 1/20 0.74
MEN1 O00255 1/20 0.74
SLC28A1 O00337 1/20 0.74
MAP3K7 O43318 1/20 0.74
SLC28A2 O43868 1/20 0.74
GAPDH P04406 1/20 0.74
ADORA3 P0DMS8 1/20 0.74
MAPK1 P28482 1/20 0.74
ADORA2A P29274 1/20 0.74
ADORA2B P29275 1/20 0.74
ADORA1 P30542 1/20 0.74
STAT6 P42226 1/20 0.74
PI4KA P42356 1/20 0.74
KMT2A Q03164 1/20 0.74
SMN1; SMN2 Q16637 1/20 0.74
PI4K2B Q8TCG2 1/20 0.74
DOT1L Q8TEK3 1/20 0.74
SLC29A1 Q99808 1/20 0.74
PI4K2A Q9BTU6 1/20 0.74
SLC28A3 Q9HAS3 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL59610 1.00 DPP4 (0.74) DPP4MEN1SLC28A1MAP3K7SLC28A2
SCHEMBL13986299 1.00 DPP4 (0.74) DPP4MEN1SLC28A1MAP3K7SLC28A2
SCHEMBL6902125 0.95 PRMT5 (0.73) DPP4MEN1SLC28A1MAP3K7SLC28A2
SCHEMBL6899705 0.93 DPP4 (0.69) DPP4MEN1SLC28A1MAP3K7SLC28A2
SCHEMBL6901066 0.93 DPP4 (0.69) DPP4MEN1SLC28A1MAP3K7SLC28A2
SCHEMBL6901068 0.93 DPP4 (0.69) DPP4MEN1SLC28A1MAP3K7SLC28A2
SCHEMBL25634757 0.89 DOT1L (0.69) DPP4MEN1SLC28A1MAP3K7SLC28A2
SCHEMBL19344133 0.88 PRMT5 (0.71) DPP4MEN1SLC28A1MAP3K7SLC28A2
Adenosine SCHEMBL9078217 0.86 ADORA3 (0.82) DPP4MEN1SLC28A1MAP3K7SLC28A2
Adenosine SCHEMBL23420216 0.85 ADORA3 (1.00) DPP4MEN1SLC28A1MAP3K7SLC28A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8129106-B2 Sequence-specific detection of methylation in biomolecules Max-Planck-Geselischaft zur Forderung der Wissenschaften E.V. (DE) 2012-03-06 US disclosed
US-20110165564-A1 SEQUENCE-SPECIFIC DETECTION OF METHYLATION IN BIOMOLECULES MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2011-07-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110165564-A1 SEQUENCE-SPECIFIC DETECTION OF METHYLATION IN BIOMOLECULES DNMT1, MAT2B, AHCY DPP4 4266/4885MEN1 1686/4885SLC28A1 1924/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.