SCHEMBL17318482

SCHEMBL17318482

COc1cccc(C=CC(=O)c2ccccc2Cl)n1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCL12 P48061 2/20 0.51
PTGS1 P23219 1/20 0.45
PTGS2 P35354 1/20 0.45
NFE2L2 Q16236 2/20 0.43
ABCG2 Q9UNQ0 3/20 0.43
HSP90AA1 P07900 1/20 0.42
KDM4E B2RXH2 2/20 0.41
MAPT P10636 1/20 0.41
MAOB P27338 2/20 0.41
HDAC3 O15379 2/20 0.40
HDAC4 P56524 2/20 0.40
HDAC1 Q13547 2/20 0.40
HDAC7 Q8WUI4 2/20 0.40
HDAC2 Q92769 2/20 0.40
HDAC10 Q969S8 2/20 0.40
HDAC11 Q96DB2 2/20 0.40
HDAC8 Q9BY41 2/20 0.40
HDAC6 Q9UBN7 2/20 0.40
HDAC9 Q9UKV0 2/20 0.40
HDAC5 Q9UQL6 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17318492 0.85 ABCG2 (0.61) ABCG2KDM4EMAPTMAOBKMT2A
SCHEMBL4584461 0.77 KDM4E (0.51) NFE2L2KDM4EMAPTHDAC3HDAC4
SCHEMBL1225317 0.77 KDM4E (0.49) PTGS1PTGS2KDM4EHDAC3HDAC4
SCHEMBL4584462 0.77 KDM4E (0.51) NFE2L2KDM4EMAPTHDAC3HDAC4
SCHEMBL1225315 0.77 KDM4E (0.49) PTGS1PTGS2KDM4EHDAC3HDAC4
SCHEMBL3929433 0.76 TGFBR1 (0.45) KDM4EMAPTHDAC3HDAC4HDAC1
SCHEMBL3929435 0.76 TGFBR1 (0.45) KDM4EMAPTHDAC3HDAC4HDAC1
SCHEMBL363641 0.75 CXCL12 (0.59) CXCL12PTGS1PTGS2ABCG2MAPT
SCHEMBL17318481 0.74 CXCL12 (0.61) CXCL12PTGS1PTGS2ABCG2MAPT
SCHEMBL12501357 0.73 TGFBR1 (0.44) PTGS2NFE2L2KDM4EMAPTHDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015187934-A1 FUNCTIONALIZED HETROARYL ENONES EXHIBITING NRF2 ACTIVATION AND THEIR METHOD OF USE CUREVEDA, LLC (US) 2015-12-10 WO disclosed