Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.39 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17318678 | 1.00 | RECQL (0.45) | RECQLMAPTNPSR1LMNAMEN1 | |
| SCHEMBL17318680 | 1.00 | RECQL (0.45) | RECQLMAPTNPSR1LMNAMEN1 | |
| SCHEMBL24037066 | 0.88 | RECQL (0.40) | RECQLMAPTNPSR1LMNAMEN1 | |
| SCHEMBL9049685 | 0.85 | TSHR (0.50) | RECQLLMNAKMT2AALDH1A1TSHR | |
| SCHEMBL9049678 | 0.85 | TSHR (0.50) | RECQLLMNAKMT2AALDH1A1TSHR | |
| SCHEMBL3964492 | 0.81 | KDM4E (0.47) | RECQLMAPTLMNAMEN1KMT2A | |
| SCHEMBL3964497 | 0.81 | KDM4E (0.47) | RECQLMAPTLMNAMEN1KMT2A | |
| SCHEMBL1915837 | 0.80 | RECQL (0.69) | RECQLMAPTMEN1KMT2A | |
| SCHEMBL1915838 | 0.80 | RECQL (0.69) | RECQLMAPTMEN1KMT2A | |
| SCHEMBL1915834 | 0.80 | RECQL (0.69) | RECQLMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3152191-B1 | IMPROVED PROCESS FOR MAKING DUOCARMYCIN PRODRUGS | SYNTHON BIOPHARMACEUTICALS BV (NL) | 2019-05-15 | — | — | EP | disclosed |
| US-9890159-B2 | Process for making duocarmycin prodrugs | SYNTHON BIOPHARMACEUTICALS B.V. (NL) | 2018-02-13 | — | — | US | disclosed |
| US-20170145006-A1 | PROCESS FOR MAKING DUOCARMYCIN PRODRUGS | SYNTHON BIOPHARMACEUTICALS B.V. (NL) | 2017-05-25 | — | — | US | disclosed |
| EP-3152191-A1 | IMPROVED PROCESS FOR MAKING DUOCARMYCIN PRODRUGS | Synthon Biopharmaceuticals B.V. (NL) | 2017-04-12 | — | — | EP | disclosed |
| WO-2015185142-A1 | IMPROVED PROCESS FOR MAKING DUOCARMYCIN PRODRUGS | SYNTHON BIOPHARMACEUTICALS B.V. (NL) | 2015-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170145006-A1 | PROCESS FOR MAKING DUOCARMYCIN PRODRUGS | UMPS, UNG, DNASE1 | RECQL 1925/4885MAPT 1454/4885NPSR1 3952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.