Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGAV | P06756 | 2/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049678 | 1.00 | TSHR (0.50) | TSHRCYP2C19RECQLALDH1A1ERCC5 | |
| SCHEMBL17318680 | 0.85 | RECQL (0.45) | TSHRCYP2C19RECQLALDH1A1ERCC5 | |
| SCHEMBL17318678 | 0.85 | RECQL (0.45) | TSHRCYP2C19RECQLALDH1A1ERCC5 | |
| SCHEMBL17318679 | 0.85 | RECQL (0.45) | TSHRCYP2C19RECQLALDH1A1ERCC5 | |
| SCHEMBL24587500 | 0.84 | ALDH1A1 (0.44) | TSHRALDH1A1ERCC5FEN1KDM4E | |
| SCHEMBL7947844 | 0.84 | ALDH1A1 (0.44) | TSHRALDH1A1ERCC5FEN1KDM4E | |
| SCHEMBL7328215 | 0.77 | KDM4E (0.51) | TSHRCYP2C19RECQLALDH1A1KDM4E | |
| SCHEMBL7328223 | 0.77 | KDM4E (0.51) | TSHRCYP2C19RECQLALDH1A1KDM4E | |
| SCHEMBL2224096 | 0.76 | RECQL (0.72) | TSHRCYP2C19RECQLALDH1A1KDM4E | |
| SCHEMBL7446722 | 0.76 | ALDH1A1 (0.50) | TSHRCYP2C19ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0507534-B1 | Succinic acid compounds | KISSEI PHARMACEUTICAL (JP) | 1996-02-28 | — | — | EP | disclosed |
| US-5202335-A | Hypoglycemic, antidiabetic agents | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1993-04-13 | — | — | US | disclosed |
| EP-0507534-A1 | Succinic acid compounds | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1992-10-07 | — | — | EP | disclosed |