Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 13/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18259759 | 1.00 | SLC6A3 (0.51) | SLC6A3SLC6A2SLC6A4CYP1A2CYP2D6 | |
| SCHEMBL4176760 | 1.00 | SLC6A3 (0.51) | SLC6A3SLC6A2SLC6A4CYP1A2CYP2D6 | |
| SCHEMBL11645304 | 0.82 | MAOA (0.38) | SLC6A3SLC6A2SLC6A4CYP1A2CYP2D6 | |
| SCHEMBL2494534 | 0.81 | SLC6A4 (0.53) | SLC6A3SLC6A2SLC6A4CYP1A2CYP2D6 | |
| SCHEMBL20203032 | 0.81 | SLC6A4 (0.53) | SLC6A3SLC6A2SLC6A4CYP1A2CYP2D6 | |
| SCHEMBL13272960 | 0.81 | SLC6A4 (0.53) | SLC6A3SLC6A2SLC6A4CYP1A2CYP2D6 | |
| SCHEMBL4777365 | 0.76 | SLC6A2 (0.47) | SLC6A3SLC6A2SLC6A4KCNH2 | |
| SCHEMBL12459508 | 0.75 | CACNA1F (0.39) | CYP1A2KCNH2CYP2C9 | |
| SCHEMBL1963366 | 0.75 | CACNA1F (0.39) | CYP1A2KCNH2CYP2C9 | |
| SCHEMBL3984947 | 0.73 | CYP19A1 (0.59) | SLC6A3SLC6A2SLC6A4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9205074-B2 | 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders | NEUROVANCE, INC. (US) | 2015-12-08 | — | — | US | disclosed |