Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 20/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13824515 | 0.88 | PKLR (0.52) | PKLR | |
| SCHEMBL21976449 | 0.82 | PKLR (0.70) | PKLR | |
| SCHEMBL17208264 | 0.81 | PKLR (0.69) | PKLR | |
| SCHEMBL21650944 | 0.80 | PKLR (0.44) | PKLR | |
| SCHEMBL21976382 | 0.80 | PKLR (0.71) | PKLR | |
| SCHEMBL21976446 | 0.80 | PKLR (0.71) | PKLR | |
| SCHEMBL9936551 | 0.80 | PKLR (1.00) | PKLR | |
| SCHEMBL21976674 | 0.80 | PKLR (0.67) | PKLR | |
| SCHEMBL18753272 | 0.80 | GRIN2B (0.47) | PKLR | |
| SCHEMBL23667388 | 0.79 | L3MBTL1 (0.49) | PKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651898-B1 | NOVEL N-(4-(AZETIDINE-1-CARBONYL)PHENYL)-(HETERO-)ARYLSULFONAMIDE DERIVATIVES AS PYRUVATE KINASE M2 (PMK2) MODULATORS | AGIOS PHARMACEUTICALS INC (US) | 2015-12-09 | — | — | EP | disclosed |