Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.58 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.58 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 3/20 | 0.42 |
| ▸ | INSR | P06213 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 5/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | YES1 | P07947 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1305489 | 0.87 | IRAK4 (0.72) | IRAK4MAP3K7AXLINSRSRC | |
| SCHEMBL352214 | 0.79 | IRAK4 (0.62) | IRAK4MAP3K7BACE1INSRKDR | |
| SCHEMBL30150294 | 0.74 | IRAK4 (1.00) | IRAK4MAP3K7AXLINSRSRC | |
| SCHEMBL19742917 | 0.74 | IRAK4 (1.00) | IRAK4MAP3K7AXLINSRSRC | |
| SCHEMBL14511547 | 0.73 | MAP3K7 (0.44) | IRAK4MAP3K7BACE1AXLINSR | |
| SCHEMBL352672 | 0.70 | IRAK4 (0.62) | IRAK4MAP3K7AXLINSRSRC | |
| SCHEMBL14483998 | 0.70 | IRAK4 (0.62) | IRAK4MAP3K7AXLINSRSRC | |
| SCHEMBL349754 | 0.69 | IRAK4 (0.80) | IRAK4MAP3K7AXLINSRSRC | |
| SCHEMBL10171322 | 0.68 | IRAK4 (0.60) | IRAK4MAP3K7INSRKDRMET | |
| SCHEMBL10171268 | 0.68 | IRAK4 (0.60) | IRAK4MAP3K7AXLINSRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960372-B1 | KINASE INHIBITORS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2015-12-09 | — | — | EP | disclosed |