Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1729874 | 0.88 | KMT2A (0.41) | TSHRKMT2A | |
| SCHEMBL11980489 | 0.64 | HTR5A (0.42) | TSHRKMT2AALDH1A1PABPC1L3MBTL1 | |
| SCHEMBL16068394 | 0.63 | — | — | |
| SCHEMBL27108527 | 0.63 | CYP1A2 (0.35) | TSHRUSP2 | |
| SCHEMBL119860 | 0.63 | HRH3 (0.41) | TSHRKMT2AALDH1A1PABPC1L3MBTL1 | |
| SCHEMBL8110294 | 0.63 | HRH3 (0.41) | TSHRKMT2AALDH1A1PABPC1L3MBTL1 | |
| SCHEMBL14967930 | 0.63 | TSHR (0.40) | TSHR | |
| SCHEMBL4027591 | 0.61 | PIK3CD (0.55) | TSHRKMT2AALDH1A1PABPC1L3MBTL1 | |
| SCHEMBL14967993 | 0.61 | TSHR (0.42) | TSHR | |
| SCHEMBL1730210 | 0.61 | OPRM1 (0.40) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1973407-B1 | SPIRO COMPOUNDS AND METHODS OF USE | CHEN GUOQING PAUL (US) | 2011-11-23 | — | — | EP | claimed |
| US-20110237794-A1 | Spiro Compounds And Methods Of Use | CHEN GUOQING PAUL | 2011-09-29 | — | — | US | claimed |
| US-20070167470-A1 | Spiro compounds and methods of use | CHEN GUOQING P | 2007-07-19 | — | — | US | claimed |
| EP-1973407-B1 | SPIRO COMPOUNDS AND METHODS OF USE | CHEN GUOQING PAUL (US) | 2011-11-23 | — | — | EP | disclosed |
| US-20110237794-A1 | Spiro Compounds And Methods Of Use | CHEN GUOQING PAUL | 2011-09-29 | — | — | US | disclosed |
| US-7977346-B2 | Spiro compounds and methods of use | CHEN GUOQING PAUL | 2011-07-12 | — | — | US | disclosed |
| EP-1973407-A2 | SPIRO COMPOUNDS AND METHODS OF USE | Chen, Guoqing Paul (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2007084875-A2 | SPIRO COMPOUNDS AND METHODS OF USE | CHEN GUOQING PAUL (US) | 2007-07-26 | — | — | WO | disclosed |
| US-20070167470-A1 | Spiro compounds and methods of use | CHEN GUOQING P | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237794-A1 | Spiro Compounds And Methods Of Use | TEK, KDR, EGFR | TSHR 1738/4885KMT2A 4512/4885ALDH1A1 451/4885 |
| US-20070167470-A1 | Spiro compounds and methods of use | TEK, KDR, EGFR | TSHR 1738/4885KMT2A 4512/4885ALDH1A1 451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.