Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | RORC | P51449 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PRKX | P51817 | 1/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17322891 | 0.83 | KMT2A (0.69) | KMT2AKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL15631890 | 0.83 | KMT2A (0.65) | KMT2AKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL15631842 | 0.78 | KDM4E (0.65) | KMT2AKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL15631853 | 0.78 | KMT2A (1.00) | KMT2AKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL15631875 | 0.76 | LMNA (0.69) | KMT2AKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL17326571 | 0.76 | MAPT (0.71) | KMT2AKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL15631891 | 0.76 | KDM4E (0.76) | KMT2AKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL17322872 | 0.76 | ALDH1A1 (0.71) | KMT2AKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL15631882 | 0.72 | MAPT (0.75) | KMT2AKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL15631866 | 0.72 | KMT2A (0.73) | KMT2AKDM4ESMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9738610-B2 | Indazole derivatives and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2017-08-22 | — | — | US | disclosed |
| US-9738610-B2 | Indazole derivatives and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2017-08-22 | — | — | US | disclosed |
| US-20150353503-A1 | INDAZOLE DERIVATIVES AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2015-12-10 | — | — | US | disclosed |
| US-20150353503-A1 | INDAZOLE DERIVATIVES AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2015-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353503-A1 | INDAZOLE DERIVATIVES AND USES THEREOF | CYP11B1, HSP90B1, CYP1B1 | KMT2A 4742/4885KDM4E 4525/4885SMN1; SMN2 4794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.