Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17315131 | 0.99 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Lithium Ion SCHEMBL17315130 | 0.91 | GABRA1 (0.48) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL17315114 | 0.90 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL18696058 | 0.89 | KDR (0.55) | FGFR1NTRK1RETKDRCSF1R | |
| SCHEMBL18696065 | 0.88 | NTRK1 (0.46) | FGFR1NTRK1RETKDRCSF1R | |
| SCHEMBL17315054 | 0.88 | KDR (0.54) | FGFR1NTRK1RETKDRCSF1R | |
| SCHEMBL17315048 | 0.87 | NTRK1 (0.45) | FGFR1NTRK1RETKDRCSF1R | |
| SCHEMBL18696068 | 0.86 | KDR (0.47) | KDM4EFGFR1NTRK1RETKDR | |
| SCHEMBL17315038 | 0.86 | GABRA1 (0.52) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL17315063 | 0.85 | KDR (0.47) | KDM4EFGFR1NTRK1RETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107074778-B | Benzimidazole analogs and related methods | 代表亚利桑那大学的亚利桑那校董会 | 2019-12-13 | — | — | CN | disclosed |
| US-9988371-B2 | Benzimidazole analogues and related methods | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2018-06-05 | — | — | US | disclosed |
| US-9988371-B2 | Benzimidazole analogues and related methods | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2018-06-05 | — | — | US | disclosed |
| US-20170101401-A1 | BENZIMIDAZOLE ANALOGUES AND RELATED METHODS | THE ARIZONA BOARD OF REGENTS, ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2017-04-13 | — | — | US | disclosed |
| US-20170101401-A1 | BENZIMIDAZOLE ANALOGUES AND RELATED METHODS | THE ARIZONA BOARD OF REGENTS, ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2017-04-13 | — | — | US | disclosed |
| WO-2015187818-A1 | BENZIMIDAZOLE ANALOGUES AND RELATED METHODS | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2015-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170101401-A1 | BENZIMIDAZOLE ANALOGUES AND RELATED METHODS | ABL1, BTK, JAK2 | GABRA1 784/4885GABRG2 1039/4885GABRB3 720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.