Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.34 |
| ▸ | FURIN | P09958 | 5/20 | 0.33 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | NPY4R | P50391 | 6/20 | 0.31 |
| ▸ | NPY1R | P25929 | 4/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPY2R | P49146 | 3/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.31 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19604383 | 0.90 | C3AR1 (0.42) | FURINC3AR1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL23961922 | 0.89 | FURIN (0.34) | SIRT5FURINC3AR1SIRT6SIRT1 | |
| SCHEMBL19203658 | 0.88 | FURIN (0.33) | FURINC3AR1SIRT6SIRT1LMNA | |
| SCHEMBL16091799 | 0.85 | SIRT5 (0.36) | SIRT5FURINC3AR1SIRT6SIRT1 | |
| SCHEMBL20375788 | 0.85 | SIRT5 (0.36) | SIRT5FURINC3AR1SIRT6SIRT1 | |
| SCHEMBL15499691 | 0.85 | SIRT5 (0.36) | SIRT5FURINC3AR1SIRT6SIRT1 | |
| SCHEMBL17993275 | 0.85 | SIRT5 (0.44) | SIRT5FURINC3AR1SIRT6SIRT1 | |
| SCHEMBL25092038 | 0.85 | SIRT5 (0.44) | SIRT5FURINC3AR1SIRT6SIRT1 | |
| SCHEMBL21103418 | 0.85 | SIRT5 (0.36) | SIRT5FURINC3AR1SIRT6SIRT1 | |
| SCHEMBL18661755 | 0.85 | SIRT5 (0.36) | SIRT5FURINC3AR1SIRT6SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016160615-A1 | MAYTANSINOID DERIVATIVES, CONJUGATES THEREOF, AND METHODS OF USE | REGENERON PHARMACEUTICALS, INC. (US) | 2016-10-06 | — | — | WO | disclosed |
| WO-2015187596-A2 | BIOLOGICALLY ACTIVE MOLECULE CONJUGATES, REAGENTS AND METHODS OF MANUFACTURE, AND THERAPEUTIC USES | REGENERON PHARMACEUTICALS, INC. (US) | 2015-12-10 | — | — | WO | disclosed |