Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 7/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 7/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9956520 | 1.00 | KDR (0.39) | KDRRXFP1RBP4CSNK1DCSNK1E | |
| SCHEMBL9957635 | 1.00 | KDR (0.39) | KDRRXFP1RBP4CSNK1DCSNK1E | |
| SCHEMBL9956302 | 0.89 | KDR (0.41) | KDRRXFP1RBP4CSNK1DCSNK1E | |
| SCHEMBL9955120 | 0.86 | KDR (0.40) | KDRRXFP1RBP4CSNK1DCSNK1E | |
| SCHEMBL9957101 | 0.85 | WDR5 (0.42) | KDRRXFP1RBP4CSNK1DCSNK1E | |
| SCHEMBL9955843 | 0.85 | WDR5 (0.40) | KDRRXFP1RBP4CSNK1DCSNK1E | |
| SCHEMBL9957558 | 0.84 | RBP4 (0.44) | KDRRXFP1RBP4CSNK1DCSNK1E | |
| SCHEMBL9957462 | 0.83 | RBP4 (0.44) | KDRRXFP1RBP4CSNK1DCSNK1E | |
| SCHEMBL9956979 | 0.81 | RXFP1 (0.41) | KDRRXFP1RBP4CSNK1DCSNK1E | |
| SCHEMBL9956844 | 0.81 | RXFP1 (0.43) | KDRRXFP1CSNK1DCSNK1EPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635578-B1 | 2-ARYLIMIDAZO[1,2-B]PYRIDAZINE, 2-PHENYLIMIDAZO[1,2-A]PYRIDINE, AND 2-PHENYLIMIDAZO[1,2-A]PYRAZINE DERIVATIVES | HENGRUI USA LTD (US) | 2015-12-16 | — | — | EP | disclosed |