Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 5/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15374440 | 1.00 | KMT2A (0.56) | KMT2AMEN1RIPK1POLBCYP2D6 | |
| SCHEMBL15319579 | 1.00 | KMT2A (0.56) | KMT2AMEN1RIPK1POLBCYP2D6 | |
| SCHEMBL17048478 | 0.86 | KDM4E (0.51) | OPRL1HPGDCHRM2 | |
| SCHEMBL15374438 | 0.82 | CYP3A4 (0.50) | KMT2AMEN1POLBCYP2D6CYP2C9 | |
| SCHEMBL15319169 | 0.82 | KMT2A (0.48) | KMT2AMEN1RIPK1POLBCYP2D6 | |
| SCHEMBL8913154 | 0.80 | KMT2A (0.55) | KMT2AMEN1RIPK1POLBCYP2D6 | |
| SCHEMBL3194202 | 0.80 | KMT2A (0.55) | KMT2AMEN1RIPK1POLBCYP2D6 | |
| SCHEMBL15374997 | 0.76 | METAP2 (0.58) | METAP2 | |
| SCHEMBL4068492 | 0.76 | RIPK1 (0.64) | KMT2AMEN1RIPK1POLBCYP2D6 | |
| SCHEMBL24992399 | 0.76 | KMT2A (0.61) | KMT2AMEN1RIPK1POLBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627631-B1 | PYRROLIDINONES AS METAP2 INHIBITORS | MERCK PATENT GMBH (DE) | 2015-12-16 | — | — | EP | claimed |