Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 20/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17328521 | 1.00 | METAP2 (0.56) | METAP2 | |
| SCHEMBL17328518 | 1.00 | METAP2 (0.56) | METAP2 | |
| SCHEMBL15367119 | 0.85 | METAP2 (0.65) | METAP2 | |
| SCHEMBL12469702 | 0.85 | METAP2 (0.65) | METAP2 | |
| SCHEMBL12469451 | 0.85 | METAP2 (0.65) | METAP2 | |
| SCHEMBL17328524 | 0.84 | METAP2 (0.50) | METAP2 | |
| SCHEMBL17328527 | 0.84 | METAP2 (0.50) | METAP2 | |
| SCHEMBL17328679 | 0.84 | METAP2 (0.50) | METAP2 | |
| SCHEMBL17328558 | 0.84 | LIPE (0.49) | METAP2 | |
| SCHEMBL17328560 | 0.84 | LIPE (0.49) | METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627631-B1 | PYRROLIDINONES AS METAP2 INHIBITORS | MERCK PATENT GMBH (DE) | 2015-12-16 | — | — | EP | claimed |