Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 17/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15374609 | 1.00 | METAP2 (0.56) | METAP2HSD11B1MEN1KMT2A | |
| SCHEMBL15374610 | 0.86 | METAP2 (0.54) | METAP2 | |
| SCHEMBL15374604 | 0.86 | METAP2 (0.54) | METAP2 | |
| SCHEMBL17328693 | 0.86 | METAP2 (0.54) | METAP2 | |
| SCHEMBL16413774 | 0.85 | METAP2 (0.53) | METAP2 | |
| SCHEMBL17763780 | 0.85 | METAP2 (0.53) | METAP2 | |
| SCHEMBL15319465 | 0.84 | METAP2 (0.55) | METAP2 | |
| SCHEMBL17328625 | 0.84 | METAP2 (0.52) | METAP2 | |
| SCHEMBL15374615 | 0.84 | METAP2 (0.52) | METAP2 | |
| SCHEMBL17328659 | 0.83 | METAP2 (0.51) | METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627631-B1 | PYRROLIDINONES AS METAP2 INHIBITORS | MERCK PATENT GMBH (DE) | 2015-12-16 | — | — | EP | claimed |