Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 17/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15374610 | 1.00 | METAP2 (0.54) | METAP2USP2ALDH1A1MAPK1CYP2C19 | |
| SCHEMBL15374609 | 0.86 | METAP2 (0.56) | METAP2 | |
| SCHEMBL17328599 | 0.86 | METAP2 (0.56) | METAP2 | |
| SCHEMBL15374612 | 0.86 | METAP2 (0.51) | METAP2 | |
| SCHEMBL17328659 | 0.86 | METAP2 (0.51) | METAP2 | |
| SCHEMBL15374631 | 0.85 | METAP2 (0.50) | METAP2ALDH1A1GAA | |
| SCHEMBL17328625 | 0.84 | METAP2 (0.52) | METAP2 | |
| SCHEMBL15374615 | 0.84 | METAP2 (0.52) | METAP2 | |
| SCHEMBL15374604 | 0.84 | METAP2 (0.54) | METAP2CYP2C19 | |
| SCHEMBL17763780 | 0.83 | METAP2 (0.53) | METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627631-B1 | PYRROLIDINONES AS METAP2 INHIBITORS | MERCK PATENT GMBH (DE) | 2015-12-16 | — | — | EP | claimed |