Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 16/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17328649 | 1.00 | METAP2 (0.49) | METAP2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL15367076 | 0.80 | OPRM1 (0.47) | METAP2NPC1 | |
| SCHEMBL12469702 | 0.78 | METAP2 (0.65) | METAP2 | |
| SCHEMBL15367119 | 0.78 | METAP2 (0.65) | METAP2 | |
| SCHEMBL12469451 | 0.78 | METAP2 (0.65) | METAP2 | |
| SCHEMBL9361258 | 0.77 | METAP2 (0.49) | METAP2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL15367245 | 0.77 | METAP2 (0.49) | METAP2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL15374436 | 0.77 | METAP2 (0.49) | METAP2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL21829639 | 0.77 | METAP2 (0.49) | METAP2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL305455 | 0.77 | HDAC8 (0.50) | METAP2MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627631-B1 | PYRROLIDINONES AS METAP2 INHIBITORS | MERCK PATENT GMBH (DE) | 2015-12-16 | — | — | EP | claimed |