Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.45 |
| ▸ | HTR2B | P41595 | 4/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | MLNR | O43193 | 7/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | MELK | Q14680 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycolic Acid SCHEMBL174349 | 0.91 | HTR2C (0.45) | HTR2CHTR2BHTR2AMLNRCYP2D6 | |
| Succinic Acid SCHEMBL174914 | 0.91 | HTR2C (0.45) | HTR2CHTR2BHTR2AMLNRCYP2D6 | |
| Adipic Acid SCHEMBL173690 | 0.88 | HTR2C (0.42) | HTR2CHTR2BHTR2AMLNRCYP2D6 | |
| SCHEMBL162032 | 0.87 | HTR2C (0.57) | HTR2CHTR2BHTR2AMLNRCYP2D6 | |
| Bromide SCHEMBL174563 | 0.85 | HTR2C (0.55) | HTR2CHTR2BHTR2AMLNRCYP2D6 | |
| SCHEMBL174395 | 0.85 | MLNR (0.50) | HTR2CHTR2BHTR2AMLNRCYP2D6 | |
| Alpha-Ketoglutaric Acid SCHEMBL174620 | 0.85 | MLNR (0.43) | HTR2CHTR2BHTR2AMLNRCYP2D6 | |
| Phosphoric Acid SCHEMBL174207 | 0.84 | HTR2C (0.47) | HTR2CHTR2BHTR2AMLNRCYP2D6 | |
| Sulfuric Acid SCHEMBL174597 | 0.84 | MLNR (0.52) | HTR2CHTR2BHTR2AMLNRCYP2D6 | |
| Aspartic Acid SCHEMBL175033 | 0.83 | MLNR (0.39) | HTR2CHTR2BHTR2AMLNRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611427-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT& xA; | Arena Pharmaceuticals, Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030927-A2 | MODIFIED-RELEASE DOSAGE FORMS OF 5-HT2C AGONISTS USEFUL FOR WEIGHT MANAGEMENT | ARENA PHARMACEUTICALS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |