Phosphoric Acid

Phosphoric Acid

SCHEMBL174207

ClCc1ccc2c(c1)CCNCC2.O=P(O)(O)O

nearest known ligand 0.49

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Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 2/20 0.47
HTR2B P41595 2/20 0.47
HTR2A P28223 1/20 0.47
MLNR O43193 8/20 0.46
CYP2D6 P10635 2/20 0.43
DRD2 P14416 1/20 0.41
DRD1 P21728 1/20 0.41
ADCY6 O43306 1/20 0.40
ADCY3 O60266 1/20 0.40
ADCY9 O60503 1/20 0.40
ADCY5 O95622 1/20 0.40
ADCY8 P40145 1/20 0.40
ADCY7 P51828 1/20 0.40
ADCY2 Q08462 1/20 0.40
ADCY1 Q08828 1/20 0.40
ADCY4 Q8NFM4 1/20 0.40
MELK Q14680 1/20 0.40
SLC2A1 P11166 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL162032 0.90 HTR2C (0.57) HTR2CHTR2BHTR2AMLNRCYP2D6
Bromide SCHEMBL174563 0.88 HTR2C (0.55) HTR2CHTR2BHTR2AMLNRCYP2D6
Sulfuric Acid SCHEMBL174597 0.87 MLNR (0.52) HTR2CHTR2BHTR2AMLNRCYP2D6
Malonic Acid SCHEMBL173339 0.84 HTR2C (0.45) HTR2CHTR2BHTR2AMLNRCYP2D6
Nitric Acid SCHEMBL174071 0.84 MLNR (0.47) HTR2CHTR2BHTR2AMLNRCYP2D6
Succinic Acid SCHEMBL174914 0.84 HTR2C (0.45) HTR2CHTR2BHTR2AMLNRCYP2D6
Glycolic Acid SCHEMBL174349 0.84 HTR2C (0.45) HTR2CHTR2BHTR2AMLNRCYP2D6
SCHEMBL174395 0.84 MLNR (0.50) HTR2CHTR2BHTR2AMLNRCYP2D6
Adipic Acid SCHEMBL173690 0.82 HTR2C (0.42) HTR2CHTR2BHTR2AMLNRCYP2D6
Alpha-Ketoglutaric Acid SCHEMBL174620 0.79 MLNR (0.43) HTR2CHTR2BHTR2AMLNRCYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2611449-A1 ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT Arena Pharmaceuticals, Inc. (US) 2013-07-10 EP disclosed
WO-2012030939-A1 ADMINISTRATION OF LORCASERIN TO INDIVIDUALS WITH RENAL IMPAIRMENT ARENA PHARMACEUTICALS, INC. (US) 2012-03-08 WO disclosed