Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 6/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.36 |
| ▸ | PNP | P00491 | 2/20 | 0.35 |
| ▸ | MGMT | P16455 | 3/20 | 0.34 |
| ▸ | HPRT1 | P00492 | 2/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6836084 | 0.83 | HPRT1 (0.35) | ADORA2BADORA2ACDK1CCNB1CCNA2 | |
| SCHEMBL8397617 | 0.77 | HPRT1 (0.47) | ADORA2BADORA2ACDK1CCNB1CCNA2 | |
| SCHEMBL8918790 | 0.76 | ADORA2B (0.37) | ADORA2BADORA2ACDK1CCNB1CCNA2 | |
| SCHEMBL669007 | 0.76 | ADORA2B (0.61) | ADORA2BADORA2ACDK1CCNB1CCNA2 | |
| SCHEMBL28071828 | 0.76 | PNP (0.45) | ADORA2BADORA2APNPMGMTPDE4A | |
| SCHEMBL216787 | 0.74 | HPRT1 (0.44) | ADORA2BADORA2APNPHPRT1PDE4A | |
| SCHEMBL1733413 | 0.74 | PDPK1 (0.42) | CDK1CCNB1CCNA2CDK2CCNA1 | |
| SCHEMBL27842808 | 0.73 | PDE4A (0.53) | ADORA2BADORA2APNPPDE4APDE4B | |
| SCHEMBL1047660 | 0.73 | PNP (0.45) | ADORA2BADORA2ACDK2PNPPDE4A | |
| SCHEMBL874737 | 0.73 | ADORA2A (0.56) | ADORA2BADORA2APNPPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222257-B2 | Phosphono-pent-2-en-1-yl nucleosides and analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-17 | — | — | US | claimed |
| EP-1866319-B1 | PHOSPHONO-PENT-2-EN-1-YL NUCLEOSIDES AND ANALOGS | UNIV CALIFORNIA (US) | 2011-11-23 | — | — | EP | claimed |
| US-20090215726-A1 | Phosphono-Pent-2-en-1-yl Nucleosides and Analogs | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-08-27 | — | — | US | claimed |
| US-20130018018-A1 | NOVEL NUCLEOSIDE PHOSPHONATES AND ANALOGS | Epiphany Biosciences ,Inc. (US) | 2013-01-17 | — | — | US | disclosed |
| US-8222257-B2 | Phosphono-pent-2-en-1-yl nucleosides and analogs | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-07-17 | — | — | US | disclosed |
| EP-1866319-B1 | PHOSPHONO-PENT-2-EN-1-YL NUCLEOSIDES AND ANALOGS | UNIV CALIFORNIA (US) | 2011-11-23 | — | — | EP | disclosed |
| US-20090215726-A1 | Phosphono-Pent-2-en-1-yl Nucleosides and Analogs | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-08-27 | — | — | US | disclosed |
| US-20090156545-A1 | Substituted Phosphate Esters of Nucleoside Phosphonates | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156545-A1 | Substituted Phosphate Esters of Nucleoside Phosphonates | PNP, TYMP, ENPP1 | ADORA2B 1260/4885ADORA2A 734/4885CDK1 361/4885 |
| US-20090215726-A1 | Phosphono-Pent-2-en-1-yl Nucleosides and Analogs | PNP, TYMP, ENPP1 | ADORA2B 1786/4885ADORA2A 510/4885CDK1 252/4885 |
| US-20130018018-A1 | NOVEL NUCLEOSIDE PHOSPHONATES AND ANALOGS | PNP, TYMP, ENTPD5 | ADORA2B 1947/4885ADORA2A 726/4885CDK1 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.