Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.49 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | LITAF | Q99732 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.38 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338191 | 0.86 | PIK3R2 (0.52) | PIK3CDPIK3R2PIK3CGCNR1CNR2 | |
| SCHEMBL17338324 | 0.85 | PIK3CD (0.49) | PIK3CDPIK3R2PIK3CGCNR1CNR2 | |
| SCHEMBL17331074 | 0.85 | PIK3CD (0.70) | PIK3CDPIK3R2PIK3CG | |
| SCHEMBL17338221 | 0.84 | PIK3CD (0.48) | PIK3CDPIK3R2PIK3CGOPRM1OPRD1 | |
| SCHEMBL17338336 | 0.82 | PIK3CD (0.68) | PIK3CDPIK3R2PIK3CG | |
| SCHEMBL17338338 | 0.82 | PIK3CD (0.68) | PIK3CDPIK3R2PIK3CG | |
| SCHEMBL17338211 | 0.81 | PIK3CD (0.49) | PIK3CDPIK3R2PIK3CG | |
| SCHEMBL17338223 | 0.79 | OPRM1 (0.44) | PIK3CDOPRM1OPRD1OGFRL1TNF | |
| SCHEMBL17338184 | 0.78 | OPRM1 (0.44) | PIK3CDOPRM1OPRD1OGFRL1TNF | |
| SCHEMBL17338218 | 0.77 | PIK3CD (0.49) | PIK3CDPIK3R2PIK3CGCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154958-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015191752-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-12-17 | — | — | WO | disclosed |