Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R2 | O00459 | 16/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338258 | 0.88 | PIK3CD (0.53) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL17338182 | 0.86 | PIK3CD (0.49) | PIK3R2PIK3CDPIK3CGCNR1CNR2 | |
| SCHEMBL17338352 | 0.85 | PIK3CD (0.68) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL17338190 | 0.84 | PIK3CD (0.74) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL22493120 | 0.84 | PIK3CD (0.74) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL17338208 | 0.84 | PIK3CD (0.52) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL17338211 | 0.81 | PIK3CD (0.49) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL17338223 | 0.79 | OPRM1 (0.44) | PIK3CD | |
| SCHEMBL17338221 | 0.79 | PIK3CD (0.48) | PIK3R2PIK3CDPIK3CG | |
| SCHEMBL17338184 | 0.79 | OPRM1 (0.44) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154958-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015191752-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-12-17 | — | — | WO | disclosed |