Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.50 |
| ▸ | PIK3R2 | O00459 | 10/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338359 | 0.89 | PIK3CD (0.52) | PIK3CDPIK3R2SIGMAR1 | |
| SCHEMBL17338181 | 0.89 | PIK3CD (0.53) | PIK3CDPIK3R2SIGMAR1 | |
| SCHEMBL17338222 | 0.86 | PIK3CD (0.47) | PIK3CDPIK3R2MEN1KMT2A | |
| SCHEMBL17338167 | 0.83 | PIK3CD (0.48) | PIK3CDPIK3R2MEN1KMT2A | |
| SCHEMBL17338152 | 0.79 | PIK3CD (0.50) | PIK3CDPIK3R2 | |
| SCHEMBL17338385 | 0.79 | PIK3CD (0.48) | PIK3CDPIK3R2 | |
| SCHEMBL17338200 | 0.79 | PIK3CD (0.54) | PIK3CDPIK3R2 | |
| SCHEMBL20525273 | 0.79 | PIK3CD (0.63) | PIK3CDPIK3R2 | |
| SCHEMBL20525274 | 0.79 | PIK3CD (0.63) | PIK3CDPIK3R2 | |
| SCHEMBL17338314 | 0.79 | PIK3CD (0.53) | PIK3CDPIK3R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154958-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015191752-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-12-17 | — | — | WO | disclosed |