Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.49 |
| ▸ | PIK3R2 | O00459 | 13/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338186 | 0.87 | PIK3CD (0.48) | PIK3CDPIK3R2 | |
| SCHEMBL17338394 | 0.84 | CYP3A4 (0.40) | PIK3CDPIK3R2 | |
| SCHEMBL17330494 | 0.83 | PIK3CD (0.72) | PIK3CDPIK3R2PIK3CB | |
| SCHEMBL17330495 | 0.83 | PIK3CD (0.72) | PIK3CDPIK3R2PIK3CB | |
| SCHEMBL17338330 | 0.83 | PIK3CD (0.66) | PIK3CDPIK3R2PIK3CB | |
| SCHEMBL17338195 | 0.82 | PIK3CD (0.43) | PIK3CDPIK3R2 | |
| SCHEMBL17338253 | 0.82 | PIK3CD (0.51) | PIK3CDPIK3R2 | |
| SCHEMBL17338168 | 0.79 | POLB (0.40) | — | |
| SCHEMBL17338459 | 0.78 | CYP3A4 (0.38) | — | |
| SCHEMBL17338250 | 0.77 | PIK3CD (0.48) | PIK3CDPIK3R2PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154958-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015191752-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-12-17 | — | — | WO | disclosed |