Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.51 |
| ▸ | PIK3R2 | O00459 | 9/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338267 | 0.94 | PIK3CD (0.49) | PIK3CDPIK3R2MKNK1CNR1CNR2 | |
| SCHEMBL17338258 | 0.88 | PIK3CD (0.53) | PIK3CDPIK3R2PIK3CG | |
| SCHEMBL17338195 | 0.87 | PIK3CD (0.43) | PIK3CDPIK3R2MKNK1CNR1CNR2 | |
| SCHEMBL17338208 | 0.84 | PIK3CD (0.52) | PIK3CDPIK3R2PIK3CG | |
| SCHEMBL17330625 | 0.84 | PIK3CD (0.73) | PIK3CDPIK3R2PIK3CG | |
| SCHEMBL17330624 | 0.84 | PIK3CD (0.73) | PIK3CDPIK3R2PIK3CG | |
| SCHEMBL17338350 | 0.84 | PIK3CD (0.68) | PIK3CDPIK3R2PIK3CG | |
| SCHEMBL17338241 | 0.82 | PIK3CD (0.49) | PIK3CDPIK3R2 | |
| SCHEMBL17338160 | 0.81 | PIK3CD (0.48) | PIK3CDPIK3R2MKNK1CNR1CNR2 | |
| SCHEMBL17338394 | 0.81 | CYP3A4 (0.40) | PIK3CDPIK3R2CNR1GPR119CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154958-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015191752-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-12-17 | — | — | WO | disclosed |