Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.37 |
| ▸ | PIK3R2 | O00459 | 6/20 | 0.37 |
| ▸ | VEGFA | P15692 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338168 | 0.94 | POLB (0.40) | CYP3A4CYP3A5POLBMEN1KMT2A | |
| SCHEMBL17338459 | 0.93 | CYP3A4 (0.38) | CYP3A4CYP3A5POLBMEN1KMT2A | |
| SCHEMBL17338241 | 0.84 | PIK3CD (0.49) | PIK3CDPIK3R2 | |
| SCHEMBL17338397 | 0.84 | POLB (0.41) | CYP3A4CYP3A5POLBPIK3CDPIK3R2 | |
| SCHEMBL17330920 | 0.84 | PIK3CD (0.46) | CYP3A4CYP3A5POLBMEN1KMT2A | |
| SCHEMBL17330919 | 0.84 | PIK3CD (0.46) | CYP3A4CYP3A5POLBMEN1KMT2A | |
| SCHEMBL17338195 | 0.81 | PIK3CD (0.43) | CYP3A4CYP3A5MEN1KMT2APIK3CD | |
| SCHEMBL17330851 | 0.81 | PIK3R2 (0.43) | CYP3A4CYP3A5POLBMEN1KMT2A | |
| SCHEMBL17330853 | 0.81 | PIK3R2 (0.43) | CYP3A4CYP3A5POLBMEN1KMT2A | |
| SCHEMBL17338253 | 0.81 | PIK3CD (0.51) | CYP3A4CYP3A5PIK3CDPIK3R2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154958-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | Gilead Sciences, Inc. (US) | 2017-04-19 | — | — | EP | disclosed |
| WO-2015191752-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-12-17 | — | — | WO | disclosed |