Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.62 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.62 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.62 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | TACR3 | P29371 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | PYGL | P06737 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338597 | 0.90 | GABRA1 (0.63) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL17338600 | 0.90 | GABRA1 (0.60) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL17338608 | 0.90 | GABRA1 (0.60) | GABRA1GABRB2GABRB1GABRA3 | |
| SCHEMBL17338559 | 0.88 | GABRA1 (0.64) | GABRA1GABRB2GABRB1GABRA3ALDH1A1 | |
| SCHEMBL17338563 | 0.86 | GABRA1 (0.62) | GABRA1GABRB2GABRB1GABRA3ALDH1A1 | |
| SCHEMBL17338586 | 0.85 | ALDH1A1 (0.54) | GABRA1GABRB2GABRB1GABRA3KDM4E | |
| SCHEMBL17338578 | 0.83 | GABRA1 (0.60) | GABRA1GABRB2GABRB1GABRA3POLB | |
| SCHEMBL17338544 | 0.83 | GABRA1 (0.60) | GABRA1GABRB2GABRB1GABRA3POLB | |
| SCHEMBL17338589 | 0.83 | GABRA1 (0.64) | GABRA1GABRB2GABRB1GABRA3POLB | |
| SCHEMBL17338567 | 0.83 | GABRA1 (0.64) | GABRA1GABRB2GABRB1GABRA3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145914-A1 | AGENTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES STRUCTURALLY BASED ON 4(1 H)-QUINOLONE | UCL Business PLC (GB) | 2017-03-29 | — | — | EP | disclosed |
| WO-2015189560-A1 | AGENTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES STRUCTURALLY BASED ON 4(1 H)-QUINOLONE | UCL BUSINESS PLC (GB) | 2015-12-17 | — | — | WO | disclosed |