Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338648 | 0.92 | POLB (0.46) | POLBSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL17338624 | 0.91 | POLB (0.45) | POLBSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL17338555 | 0.91 | POLB (0.49) | POLBSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL17338635 | 0.88 | POLB (0.46) | POLBSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL17338614 | 0.88 | POLB (0.46) | POLBSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL17338586 | 0.87 | ALDH1A1 (0.54) | POLBSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL17338634 | 0.86 | POLB (0.47) | POLBSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL17338563 | 0.85 | GABRA1 (0.62) | POLBSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL17338642 | 0.84 | POLB (0.44) | POLBSMN1; SMN2LMNAMAPTALDH1A1 | |
| SCHEMBL17338641 | 0.83 | ITGB2 (0.44) | POLBSMN1; SMN2LMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145914-A1 | AGENTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES STRUCTURALLY BASED ON 4(1 H)-QUINOLONE | UCL Business PLC (GB) | 2017-03-29 | — | — | EP | disclosed |
| WO-2015189560-A1 | AGENTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES STRUCTURALLY BASED ON 4(1 H)-QUINOLONE | UCL BUSINESS PLC (GB) | 2015-12-17 | — | — | WO | disclosed |