Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27984769 | 0.89 | SMN1; SMN2 (0.48) | MAPK1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL6219618 | 0.86 | MAPK1 (0.48) | MAPK1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL25515640 | 0.81 | MAPT (0.48) | MAPK1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL8122403 | 0.81 | HTT (0.45) | MAPK1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL4616746 | 0.80 | KDM4E (0.64) | MAPK1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL6248007 | 0.78 | L3MBTL1 (0.40) | MAPK1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL21358704 | 0.77 | MEN1 (0.41) | HTTATML3MBTL1MEN1KMT2A | |
| SCHEMBL14963083 | 0.76 | KDM4E (0.49) | MAPK1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL14963077 | 0.75 | ALDH1A1 (0.48) | MAPK1ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL17339205 | 0.75 | KDM4E (0.58) | MAPK1ALDH1A1KDM4EGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111892579-B | Kinase inhibitors | 上海艾力斯医药科技股份有限公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-116134035-A | 3- (1H-imidazol-2-yl) -2,3,8 a-tetrahydroindol-5 (1H) -one derivatives useful as factor XIA inhibitors | 詹森药业有限公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-111892579-A | Kinase inhibitor | 上海复尚慧创医药研究有限公司 | 2020-11-06 | — | — | CN | disclosed |
| CN-111875585-A | Kinase inhibitor | 上海复尚慧创医药研究有限公司 | 2020-11-03 | — | — | CN | disclosed |
| CN-106660993-B | Kinase inhibitor | 上海复尚慧创医药研究有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-106660993-A | Kinase inhibitor | 上海复尚慧创医药研究有限公司 | 2017-05-10 | — | — | CN | disclosed |
| WO-2015188777-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO LTD (CN) | 2015-12-17 | — | — | WO | disclosed |