⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6647074 | 0.81 | EPHX1 (0.43) | — | |
| SCHEMBL23728842 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL6646763 | 0.79 | EPHX1 (0.42) | — | |
| Hydrochloric Acid SCHEMBL6649073 | 0.79 | EPHX1 (0.42) | — | |
| SCHEMBL25520066 | 0.79 | — | — | |
| SCHEMBL24470495 | 0.77 | ACHE (0.61) | — | |
| SCHEMBL6139622 | 0.75 | EPHX1 (0.39) | — | |
| SCHEMBL27934398 | 0.75 | EPHX1 (0.39) | — | |
| SCHEMBL249164 | 0.75 | — | — | |
| SCHEMBL25518166 | 0.73 | CHRNB2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4387971-A1 | N-CYCLOPROPYLPYRIDO [4, 3-D] PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | Jacobio Pharmaceuticals Co., Ltd. (CN) | 2024-06-26 | — | — | EP | disclosed |
| WO-2024043319-A1 | ANTIBODY-DRUG COMPLEX | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 2024-02-29 | — | — | WO | disclosed |
| WO-2023202655-A1 | FAP INHIBITORS | SHANGHAI SINOTAU BIOTECH. CO., LTD (CN) | 2023-10-26 | — | — | WO | disclosed |
| EP-4225729-A1 | IONIZABLE LIPIDS AND COMPOSITIONS FOR NUCLEIC ACID DELIVERY | Westgene Biopharma Co., Ltd. (CN) | 2023-08-16 | — | — | EP | disclosed |
| US-20230159569-A1 | DUAL HDAC6/PROTEASOME INHIBITORS, AND METHODS OF USE THEREOF | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2023-05-25 | — | — | US | disclosed |
| WO-2023078021-A1 | BCMA MONOCLONAL ANTIBODY AND THE ANTIBODY-DRUG CONJUGATE | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023078273-A1 | SPECIFIC CONJUGATION FOR AN ANTIBODY-DRUG CONJUGATE | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2023-05-11 | — | — | WO | disclosed |
| CN-109562111-B | CK2 inhibitors, compositions and methods thereof | 北极星药业股份有限公司 | 2023-04-04 | — | — | CN | disclosed |
| WO-2023020518-A1 | N-CYCLOPROPYLPYRIDO [4, 3-D] PYRIMIDIN-4-AMINE DERIVATIVES AND USES THEREOF | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2023-02-23 | — | — | WO | disclosed |
| CN-109265400-B | Arginine methyltransferase inhibitors and uses thereof | EPIZYME股份有限公司 | 2022-10-04 | — | — | CN | disclosed |
| EP-3921320-A1 | IMIDAZO [2, 1-F] [1, 2, 4] TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST | BeiGene, Ltd. (KY) | 2021-12-15 | — | — | EP | disclosed |
| EP-3917936-A1 | ALKYLBORONIC ACIDS AS ARGINASE INHIBITORS | Guangdong Newopp Biopharmaceuticals Co., Ltd. (CN) | 2021-12-08 | — | — | EP | disclosed |
| CN-113614095-A | Alkylboronic acids as arginase inhibitors | 广东新契生物医药科技有限公司 | 2021-11-05 | — | — | CN | disclosed |
| CN-107205961-B | Prodrugs of phenolic TRPV1 agonists | 同心镇痛药物公司 | 2021-03-16 | — | — | CN | disclosed |
| WO-2020160711-A1 | IMIDAZO [2, 1-F] [1, 2, 4] TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST | BEIGENE, LTD. (KY) | 2020-08-13 | — | — | WO | disclosed |
| WO-2020160707-A1 | ALKYLBORONIC ACIDS AS ARGINASE INHIBITORS | GUANGDONG NEWOPP BIOPHARMACEUTICALS CO., LTD. (CN) | 2020-08-13 | — | — | WO | disclosed |
| EP-3303366-A1 | DERIVATIVES OF DOLASTATIN 10 AND USES THEREOF | Newbio Therapeutics Inc. (CN) | 2018-04-11 | — | — | EP | disclosed |
| WO-2016192527-A1 | DERIVATIVES OF DOLASTATIN 10 AND USES THEREOF | NEWBIO THERAPEUTICS, INC. (CN) | 2016-12-08 | — | — | WO | disclosed |
| CN-102917590-B | Tricyclic compound and the PBK inhibitor containing described compound | ONCOTHERAPY SCIENCE, INC. (JP) | 2016-02-17 | — | — | CN | disclosed |
| WO-2015188777-A1 | CERTAIN PROTEIN KINASE INHIBITORS | SHANGHAI FOCHON PHARMACEUTICAL CO LTD (CN) | 2015-12-17 | — | — | WO | disclosed |