Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOD1 | P00441 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13165306 | 0.83 | SOD1 (0.43) | SOD1LMNAPOLBHTTL3MBTL1 | |
| SCHEMBL13165331 | 0.83 | SOD1 (0.43) | SOD1LMNAPOLBHTTL3MBTL1 | |
| SCHEMBL2742871 | 0.75 | SOD1 (0.44) | SOD1LMNAPOLBHTTL3MBTL1 | |
| SCHEMBL12062257 | 0.75 | SOD1 (0.44) | SOD1LMNAPOLBHTTL3MBTL1 | |
| SCHEMBL10064809 | 0.74 | GRM2 (0.50) | SOD1LMNAPOLBHTTL3MBTL1 | |
| SCHEMBL12062270 | 0.73 | SOD1 (0.42) | SOD1LMNAPOLBHTTL3MBTL1 | |
| SCHEMBL11937239 | 0.72 | GRM2 (0.48) | SOD1LMNAPOLBHTTL3MBTL1 | |
| SCHEMBL20347939 | 0.72 | GRM2 (0.48) | SOD1LMNAPOLBHTTL3MBTL1 | |
| SCHEMBL29979999 | 0.71 | CYP3A4 (0.55) | SOD1LMNAPOLBHTTL3MBTL1 | |
| SCHEMBL5619009 | 0.71 | CYP3A4 (0.55) | SOD1LMNAPOLBHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296737-B2 | Substituted 2,4-diaminopyrimidines as kinase inhibitors | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-9212181-B2 | Substituted 2,4-diaminopyrimidines as kinase inhibitors | CELGENE AVILOMICS RESEARCH, INC. (US) | 2015-12-15 | — | — | US | disclosed |