Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL328280 | 0.85 | ALDH1A1 (0.39) | PTK2MAPK14TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL10156687 | 0.76 | MAPK14 (0.43) | MAPK14MAPK13LCKMAPK12MAPK11 | |
| SCHEMBL10155938 | 0.74 | PLAU (0.38) | PTK2MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL10126661 | 0.72 | LRRK2 (0.48) | PTK2LRRK2 | |
| SCHEMBL10157671 | 0.71 | SCN9A (0.37) | MAPK14EGFRPLK1PLAU | |
| SCHEMBL13657185 | 0.67 | HDAC8 (0.48) | TAS1R3TAS1R1TAS1R2HPGDRAB9A | |
| SCHEMBL10128876 | 0.66 | ALK (0.57) | — | |
| SCHEMBL10126643 | 0.66 | EML4 (0.43) | EGFR | |
| SCHEMBL15042794 | 0.65 | LRRK2 (0.67) | PTK2LRRK2 | |
| SCHEMBL12229696 | 0.64 | MAPK14 (0.47) | MAPK14MAPK13LCKMAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428508-B9 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-04-20 | — | — | EP | disclosed |
| EP-2428508-B1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2015-12-16 | — | — | EP | disclosed |