Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | F3 | P13726 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 3/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10127120 | 0.91 | PARP1 (0.39) | PARP1PARP10F7F3MKNK1 | |
| SCHEMBL10157871 | 0.76 | MKNK1 (0.45) | PARP1PARP10F7F3MKNK1 | |
| SCHEMBL10127092 | 0.76 | PARP1 (0.43) | PARP1PARP10F7F3MKNK1 | |
| SCHEMBL10128342 | 0.69 | SYK (0.36) | PARP1PARP10F7F3MKNK1 | |
| SCHEMBL10127107 | 0.67 | PDE4B (0.43) | MKNK1CCNA2CDK2GFERXDH | |
| SCHEMBL10127269 | 0.67 | GFER (0.43) | GFERRXFP1XDHJAK2 | |
| SCHEMBL10127056 | 0.66 | GFER (0.47) | GFERRXFP1XDH | |
| SCHEMBL11906514 | 0.66 | PARP10 (0.56) | PARP1PARP10F7F3MKNK1 | |
| SCHEMBL10126487 | 0.65 | XDH (0.44) | GFERRXFP1XDHSLC22A12 | |
| SCHEMBL10126560 | 0.65 | XDH (0.42) | GFERRXFP1XDHSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428508-B1 | DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2015-12-16 | — | — | EP | disclosed |