Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 1/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15314772 | 0.88 | VEGFA (0.77) | VEGFAEGLN1ALDH1A1DRD2DRD4 | |
| SCHEMBL1770695 | 0.87 | VEGFA (0.78) | VEGFAEGLN1ALDH1A1DRD2DRD4 | |
| SCHEMBL17005908 | 0.81 | VEGFA (0.66) | VEGFAEGLN1ALDH1A1DRD2DRD4 | |
| SCHEMBL17005962 | 0.79 | VEGFA (0.67) | VEGFAEGLN1ALDH1A1DRD2DRD4 | |
| SCHEMBL11093397 | 0.79 | DRD2 (0.70) | ALDH1A1DRD2DRD4TSHRKDM4E | |
| SCHEMBL1770457 | 0.78 | EGLN1 (0.63) | VEGFAEGLN1ALDH1A1DRD2DRD4 | |
| SCHEMBL1770870 | 0.78 | VEGFA (0.71) | VEGFAEGLN1ALDH1A1DRD2DRD4 | |
| SCHEMBL30963341 | 0.78 | EGLN1 (0.63) | VEGFAEGLN1ALDH1A1DRD2DRD4 | |
| SCHEMBL17005862 | 0.78 | VEGFA (0.64) | VEGFAEGLN1ALDH1A1DRD2DRD4 | |
| SCHEMBL1770264 | 0.78 | VEGFA (0.64) | VEGFAEGLN1ALDH1A1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2954899-A1 | COMPOSITIONS AND METHODS FOR TREATING COLITIS | Aerpio Therapeutics, Inc. (US) | 2015-12-16 | — | — | EP | disclosed |