Sugi Predict

Sugi Predict / Compounds / SCHEMBL1770870

SCHEMBL1770870

SCHEMBL1770870

CCCCOC(=O)N1CCN(Cc2ccn(Cc3ccc(Cl)cc3)c(=O)c2O)CC1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ VEGFA P15692 5/20 0.71
▸ EGLN1 Q9GZT9 5/20 0.71
▸ ALDH1A1 P00352 5/20 0.46
▸ TSHR P16473 2/20 0.46
▸ KDM4E B2RXH2 2/20 0.46
▸ DRD2 P14416 1/20 0.45
▸ DRD4 P21917 1/20 0.45
▸ HRH2 P25021 2/20 0.45
▸ HRH1 P35367 2/20 0.45
▸ HTT P42858 3/20 0.42
▸ CYP1A2 P05177 2/20 0.42
▸ CYP2C19 P33261 2/20 0.42
▸ CYP2D6 P10635 1/20 0.42
▸ CYP2C9 P11712 1/20 0.42
▸ SMN1; SMN2 Q16637 1/20 0.42
▸ OPRD1 P41143 1/20 0.42
▸ OPRK1 P41145 1/20 0.42
▸ PLA2G7 Q13093 1/20 0.41
▸ MGLL Q99685 1/20 0.41
▸ ABHD6 Q9BV23 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1770695 0.91 VEGFA (0.78) VEGFAEGLN1ALDH1A1TSHRKDM4E
SCHEMBL1770487 0.86 VEGFA (0.79) VEGFAEGLN1ALDH1A1TSHRKDM4E
SCHEMBL17005962 0.84 VEGFA (0.67) VEGFAEGLN1ALDH1A1TSHRKDM4E
SCHEMBL14900076 0.83 VEGFA (0.82) VEGFAEGLN1ALDH1A1TSHRKDM4E
SCHEMBL17005908 0.83 VEGFA (0.66) VEGFAEGLN1ALDH1A1TSHRKDM4E
Izilendustat SCHEMBL1770480 0.83 VEGFA (1.00) VEGFAEGLN1ALDH1A1TSHRKDM4E
SCHEMBL17005929 0.83 VEGFA (0.63) VEGFAEGLN1ALDH1A1TSHRKDM4E
SCHEMBL15035749 0.83 VEGFA (0.84) VEGFAEGLN1ALDH1A1TSHRKDM4E
SCHEMBL14900097 0.83 VEGFA (0.84) VEGFAEGLN1ALDH1A1TSHRKDM4E
SCHEMBL17005862 0.82 VEGFA (0.64) VEGFAEGLN1ALDH1A1TSHRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220185778-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS INC (US) 2022-06-16 — — US disclosed
US-10562854-B2 Prolyl hydroxylase inhibitors AERPIO THERAPEUTICS, INC. (US) 2020-02-18 — — US disclosed
EP-3603644-A1 PROLYL HYDROXYLASE INHIBITORS Aerpio Therapeutics, Inc. (US) 2020-02-05 — — EP disclosed
US-20190055198-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS LLC 2019-02-21 — — US disclosed
US-20170298019-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS LLC 2017-10-19 — — US disclosed
EP-2853265-B1 Methods for increasing the stabilization of hypoxia inducible factor-1 alpha AERPIO THERAPEUTICS INC (US) 2017-07-26 — — EP disclosed
EP-2954899-A1 COMPOSITIONS AND METHODS FOR TREATING COLITIS Aerpio Therapeutics, Inc. (US) 2015-12-16 — — EP disclosed
EP-2952192-A1 Prolyl hydroxylase inhibitors Aerpio Therapeutics Inc. (US) 2015-12-09 — — EP disclosed
US-20150218098-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS LLC 2015-08-06 — — US disclosed
US-9045495-B2 Prolyl hydroxylase inhibitors AERPIO THERAPEUTICS INC. (US) 2015-06-02 — — US disclosed
US-20130158045-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS INC. (US) 2013-06-20 — — US disclosed
EP-2496236-B1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS INC (US) 2013-05-01 — — EP disclosed
US-8309537-B2 Compositions and methods for treating colitis AERPIO THERAPEUTICS INC. (US) 2012-11-13 — — US disclosed
US-8309537-B2 Compositions and methods for treating colitis AERPIO THERAPEUTICS INC. (US) 2012-11-13 — — US disclosed
US-20110112055-A1 COMPOSITIONS AND METHODS FOR TREATING COLITIS AERPIO THERAPEUTICS LLC 2011-05-12 — — US disclosed
US-20110110961-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS LLC 2011-05-12 — — US disclosed
US-20110112055-A1 COMPOSITIONS AND METHODS FOR TREATING COLITIS AERPIO THERAPEUTICS LLC 2011-05-12 — — US disclosed
US-20110110961-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS LLC 2011-05-12 — — US disclosed
US-20110111058-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2011-05-12 — — US disclosed
US-20110111058-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2011-05-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170298019-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, HIF1A, EGLN2 VEGFA 551/4885EGLN1 5/4885ALDH1A1 652/4885
US-20110112055-A1 COMPOSITIONS AND METHODS FOR TREATING COLITIS ALPI, SI, SLC10A2 VEGFA 4546/4885EGLN1 2861/4885ALDH1A1 780/4885
US-20130158045-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, HIF1A, EGLN2 VEGFA 551/4885EGLN1 5/4885ALDH1A1 652/4885
US-20190055198-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, HIF1A, EGLN2 VEGFA 551/4885EGLN1 5/4885ALDH1A1 652/4885
US-20220185778-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, HIF1A, EGLN2 VEGFA 551/4885EGLN1 5/4885ALDH1A1 652/4885
US-20110111058-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 VEGFA 20/4885EGLN1 8/4885ALDH1A1 505/4885
US-20150218098-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, HIF1A, EGLN2 VEGFA 551/4885EGLN1 5/4885ALDH1A1 652/4885
US-20110110961-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, HIF1A, EGLN2 VEGFA 551/4885EGLN1 5/4885ALDH1A1 652/4885
US-10562854-B2 Prolyl hydroxylase inhibitors HIF1AN, HIF1A, EGLN2 VEGFA 551/4885EGLN1 5/4885ALDH1A1 652/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.