Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 5/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10399442 | 0.74 | DHFR (0.34) | SLC2A1DHFRCDK1CCNB1CCNE1 | |
| SCHEMBL11443982 | 0.73 | ADORA2A (0.37) | — | |
| SCHEMBL12368246 | 0.70 | HEXA (0.58) | DHFRGHSR | |
| SCHEMBL17342568 | 0.69 | TLR8 (0.44) | SLC2A1DHFR | |
| SCHEMBL17343117 | 0.68 | KDM4E (0.40) | CDK2 | |
| SCHEMBL5491792 | 0.67 | TDP1 (0.38) | CDK2 | |
| SCHEMBL602820 | 0.67 | ALDH1A1 (0.34) | DHFRGHSR | |
| SCHEMBL20782341 | 0.67 | ADORA2A (0.35) | — | |
| SCHEMBL18874069 | 0.66 | HTT (0.50) | — | |
| SCHEMBL9287273 | 0.66 | GCGR (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3154969-B1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2019-10-09 | — | — | EP | disclosed |
| US-20150361095-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2015-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150361095-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3CA, AKT3, PIK3CD | SLC2A1 1644/4885DHFR 3505/4885CDK1 49/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.