Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 7/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | PRNP | P04156 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4178072 | 0.98 | PRKDC (0.52) | PRKDCHTTPDGFRBMAP4K4JAK3 | |
| SCHEMBL1585491 | 0.95 | HTT (0.51) | PRKDCHTTPDGFRBPTK2ALDH1A1 | |
| SCHEMBL6785138 | 0.85 | HTT (0.70) | HTTPDGFRBALDH1A1LMNAMAPK1 | |
| SCHEMBL3115181 | 0.81 | HTT (0.74) | PRKDCHTTPDGFRBMAP4K4JAK3 | |
| SCHEMBL14595394 | 0.79 | CHRM4 (0.58) | HTTPDGFRBALDH1A1LMNAMAPK1 | |
| SCHEMBL2725752 | 0.79 | PDGFRB (0.48) | HTTPDGFRBPTK2ALDH1A1LMNA | |
| SCHEMBL2882279 | 0.78 | PRKDC (0.47) | PRKDCHTTMAP4K4JAK3ALDH1A1 | |
| SCHEMBL30821993 | 0.77 | PTK2 (0.71) | PRKDCHTTJAK3PTK2ALDH1A1 | |
| SCHEMBL6569122 | 0.77 | PTK2 (0.71) | PRKDCHTTJAK3PTK2ALDH1A1 | |
| SCHEMBL4356019 | 0.77 | HTT (0.55) | HTTMAP4K4ALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318932-B2 | Process for producing 4-aminoquinazoline compound | UBE INDUSTRIES, LTD. (JP) | 2012-11-27 | — | — | US | disclosed |
| EP-1481971-B1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | UBE INDUSTRIES (JP) | 2011-11-16 | — | — | EP | disclosed |
| WO-2011131610-A1 | HEAT TRANSFER MEDIUM BASED ON SULPHUR AND USE OF THE HEAT TRANSFER MEDIUM | SIEMENS AKTIENGESELLSCHAFT (DE) | 2011-10-27 | — | — | WO | disclosed |
| US-20090171083-A1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | UBE INDUSTRIES, LTD. (JP) | 2009-07-02 | — | — | US | disclosed |
| US-20080177069-A1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | UBE INDUSTRIES, LTD. (JP) | 2008-07-24 | — | — | US | disclosed |
| US-20050130995-A1 | Chlorinating quinazolin-4-one in solvent in presence of a base; then reacting with an amine compound | UBE INDUSTRIES, LTD. (JP) | 2005-06-16 | — | — | US | disclosed |
| EP-1481971-A1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | Ube Industries, Ltd. (JP) | 2004-12-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090171083-A1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | HRH4, CYP3A4, HRH3 | PRKDC 1033/4885HTT 1926/4885PDGFRB 804/4885 |
| US-20080177069-A1 | PROCESS FOR PRODUCING 4-AMINOQUINAZOLINE COMPOUND | HRH4, CYP3A4, HRH3 | PRKDC 1033/4885HTT 1926/4885PDGFRB 804/4885 |
| US-20050130995-A1 | Chlorinating quinazolin-4-one in solvent in presence of a base; then reacting with an amine compound | HRH4, HRH3, H1-4 | PRKDC 1394/4885HTT 2023/4885PDGFRB 1112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.