Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 13/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 13/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 11/20 | 0.44 |
| ▸ | LMNA | P02545 | 11/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 10/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 10/20 | 0.44 |
| ▸ | TSHR | P16473 | 8/20 | 0.44 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | USP2 | O75604 | 5/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730641 | 0.91 | KDM4E (0.49) | PDGFRBPTK2HRH4HTTALDH1A1 | |
| SCHEMBL1585491 | 0.80 | HTT (0.51) | PDGFRBPTK2HRH4HTTALDH1A1 | |
| SCHEMBL4178072 | 0.80 | PRKDC (0.52) | PDGFRBPTK2HRH4HTTALDH1A1 | |
| SCHEMBL1734528 | 0.79 | PRKDC (0.53) | PDGFRBPTK2HRH4HTTALDH1A1 | |
| SCHEMBL2722449 | 0.77 | EGFR (0.63) | PDGFRBHTTALDH1A1HSD17B10KDM4E | |
| SCHEMBL6785138 | 0.77 | HTT (0.70) | PDGFRBHTTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2725484 | 0.75 | EGFR (0.55) | PDGFRBHTTALDH1A1MAPK1KMT2A | |
| SCHEMBL5468434 | 0.74 | ACHE (0.68) | — | |
| SCHEMBL10072172 | 0.74 | KDM4E (0.64) | PDGFRBHRH4HTTALDH1A1CYP1A2 | |
| SCHEMBL10072150 | 0.73 | ENPP1 (0.49) | PDGFRBALDH1A1CYP1A2CYP3A4CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9006255-B2 | Quinazoline derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006255-B2 | Quinazoline derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| US-9006255-B2 | Quinazoline derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | disclosed |
| EP-2632923-B1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2632923-B1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2632923-A1 | QUINAZOLINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-09-04 | — | — | EP | disclosed |
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-15 | — | — | US | disclosed |
| WO-2012055466-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-05-03 | — | — | WO | disclosed |
| WO-2012055466-A1 | QUINAZOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130210819-A1 | QUINAZOLINE DERIVATIVES | RAB1A, PIK3R5, PIK3R1 | PDGFRB 2288/4885PTK2 996/4885HRH4 1455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.