Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17338605 | 0.91 | P2RX3 (0.57) | TP53LMNAP2RX3F2RL3TDP1 | |
| SCHEMBL18589488 | 0.90 | LMNA (0.55) | TP53LMNAP2RX3MAPTCNR2 | |
| SCHEMBL15956289 | 0.90 | LMNA (0.70) | TP53LMNAP2RX3ALDH1A1CNR2 | |
| SCHEMBL1549401 | 0.89 | P2RX3 (0.61) | TP53LMNAP2RX3MAPTALDH1A1 | |
| SCHEMBL13762896 | 0.88 | MAPT (0.69) | TP53LMNAP2RX3MAPTALDH1A1 | |
| SCHEMBL30125450 | 0.85 | P2RX3 (0.61) | TP53LMNAP2RX3MAPTCHRM1 | |
| SCHEMBL1073993 | 0.84 | TP53 (0.77) | TP53LMNAMAPTALDH1A1CNR2 | |
| SCHEMBL1549370 | 0.84 | TP53 (0.69) | TP53LMNAMAPTALDH1A1CNR2 | |
| SCHEMBL16341783 | 0.83 | CNR2 (0.63) | TP53LMNAP2RX3CNR2F2RL3 | |
| SCHEMBL11895496 | 0.83 | P2RX3 (0.62) | TP53LMNAP2RX3L3MBTL1F2RL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015189560-A1 | AGENTS FOR USE IN THE TREATMENT OF CARDIOVASCULAR AND INFLAMMATORY DISEASES STRUCTURALLY BASED ON 4(1 H)-QUINOLONE | UCL BUSINESS PLC (GB) | 2015-12-17 | — | — | WO | disclosed |