Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 18/20 | 0.54 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14697321 | 1.00 | HSD11B1 (0.54) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL14697418 | 1.00 | HSD11B1 (0.54) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL17350282 | 1.00 | HSD11B1 (0.54) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL14697322 | 1.00 | HSD11B1 (0.54) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL3041989 | 1.00 | HSD11B1 (0.54) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL12334440 | 0.83 | HSD11B1 (0.56) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL257525 | 0.83 | HSD11B1 (0.56) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL231725 | 0.82 | HSD11B1 (0.56) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL9948724 | 0.79 | THRB (0.48) | HSD11B1HSD11B2EPHX2 | |
| SCHEMBL233183 | 0.79 | HSD11B1 (0.58) | HSD11B1HSD11B2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556187-B2 | Substituted pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidines and JAK inhibitors comprising the same | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2017-01-31 | — | — | US | disclosed |
| EP-3112370-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS AND JAK INHIBITORS | Nissan Chemical Industries, Ltd. (JP) | 2017-01-04 | — | — | EP | disclosed |
| US-9216999-B2 | Substituted pyrrolo[2,3-h][1,6]naphthyridines and compositions thereof as JAK inhibitors | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2015-12-22 | — | — | US | disclosed |