Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
| ▸ | TERT | O14746 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10243942 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ANPC1PKMTP53 | |
| SCHEMBL10243840 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ANPC1PKMTP53 | |
| SCHEMBL2683527 | 0.89 | HPGD (0.47) | SMN1; SMN2RAB9ANPC1TP53MAPT | |
| SCHEMBL10244672 | 0.89 | HPGD (0.47) | SMN1; SMN2RAB9ANPC1TP53MAPT | |
| SCHEMBL1825398 | 0.89 | NPC1 (0.53) | SMN1; SMN2RAB9ANPC1PKMTP53 | |
| SCHEMBL10244105 | 0.89 | NPC1 (0.53) | SMN1; SMN2RAB9ANPC1PKMTP53 | |
| SCHEMBL10243991 | 0.88 | RAB9A (0.51) | SMN1; SMN2RAB9ANPC1LMNATSHR | |
| SCHEMBL17350898 | 0.88 | RAB9A (0.51) | SMN1; SMN2RAB9ANPC1LMNATSHR | |
| SCHEMBL10244022 | 0.87 | CASP3 (0.47) | SMN1; SMN2RAB9ANPC1PKMNFKB1 | |
| SCHEMBL17350791 | 0.87 | CASP3 (0.47) | SMN1; SMN2RAB9ANPC1PKMNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318403-B1 | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INT (DE) | 2015-12-23 | — | — | EP | disclosed |