Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10243945 | 1.00 | TSHR (0.48) | TSHRHPGDSMN1; SMN2RECQLMGLL | |
| SCHEMBL2683635 | 0.91 | TSHR (0.48) | TSHRHPGDSMN1; SMN2RECQLNPC1 | |
| SCHEMBL10243619 | 0.91 | TSHR (0.48) | TSHRHPGDSMN1; SMN2RECQLNPC1 | |
| SCHEMBL17350779 | 0.89 | ALDH1A1 (0.53) | TSHRHPGDSMN1; SMN2RECQLMGLL | |
| SCHEMBL10243882 | 0.89 | MAOB (0.51) | TSHRHPGDSMN1; SMN2RECQLNPC1 | |
| SCHEMBL2682577 | 0.89 | MAOB (0.51) | TSHRHPGDSMN1; SMN2RECQLMGLL | |
| SCHEMBL10243991 | 0.89 | RAB9A (0.51) | TSHRHPGDSMN1; SMN2RECQLMGLL | |
| SCHEMBL17350898 | 0.89 | RAB9A (0.51) | TSHRHPGDSMN1; SMN2RECQLMGLL | |
| SCHEMBL10243800 | 0.89 | ALDH1A1 (0.53) | TSHRHPGDSMN1; SMN2RECQLMGLL | |
| SCHEMBL10243793 | 0.89 | MAOB (0.51) | TSHRHPGDSMN1; SMN2RECQLMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2318403-B1 | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INT (DE) | 2015-12-23 | — | — | EP | disclosed |