Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 8/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 8/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 8/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 8/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18874272 | 0.94 | MEN1 (0.41) | MEN1KMT2AUSP2KDM4ECYP1A2 | |
| SCHEMBL17351245 | 0.88 | CA1 (0.43) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL4568248 | 0.88 | PDK1 (0.40) | MEN1KMT2AUSP2KDM4ECYP1A2 | |
| SCHEMBL23952225 | 0.87 | PDK1 (0.44) | MEN1KMT2AUSP2KDM4ECYP1A2 | |
| SCHEMBL17351276 | 0.85 | CA1 (0.50) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL20749911 | 0.83 | MEN1 (0.38) | MEN1KMT2ACYP1A2PDK1PDK2 | |
| SCHEMBL16050285 | 0.81 | MEN1 (0.40) | MEN1KMT2APDK1PDK2PDK3 | |
| SCHEMBL4568245 | 0.80 | HDAC1 (0.41) | MEN1KMT2AUSP2KDM4ECYP1A2 | |
| SCHEMBL28600793 | 0.80 | CA1 (0.44) | MEN1KMT2AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL17351269 | 0.80 | MEN1 (0.36) | MEN1KMT2AKDM4ECYP1A2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970119-B1 | NOVEL INDOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS | MERCK SHARP & DOHME (US) | 2021-11-03 | — | — | EP | disclosed |
| EP-3517524-B1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2021-05-26 | — | — | EP | disclosed |
| EP-3517524-B1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2021-05-26 | — | — | EP | disclosed |
| EP-3517524-A1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | Merial Inc. (US) | 2019-07-31 | — | — | EP | disclosed |
| US-10251863-B2 | Parasiticidal compositions comprising indole derivatives, methods and uses thereof | MERIAL INC. (US) | 2019-04-09 | — | — | US | disclosed |
| US-10251863-B2 | Parasiticidal compositions comprising indole derivatives, methods and uses thereof | MERIAL INC. (US) | 2019-04-09 | — | — | US | disclosed |
| EP-3157912-B1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | MERIAL INC (US) | 2019-02-20 | — | — | EP | disclosed |
| EP-3157912-B1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | MERIAL INC (US) | 2019-02-20 | — | — | EP | disclosed |
| US-20170290803-A1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | MERIAL, INC. (US) | 2017-10-12 | — | — | US | disclosed |
| US-20170290803-A1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | MERIAL, INC. (US) | 2017-10-12 | — | — | US | disclosed |
| US-9776986-B2 | Parasiticidal compositions comprising indole derivatives, methods and uses thereof | MERIAL INC. (US) | 2017-10-03 | — | — | US | disclosed |
| US-9776986-B2 | Parasiticidal compositions comprising indole derivatives, methods and uses thereof | MERIAL INC. (US) | 2017-10-03 | — | — | US | disclosed |
| US-9776986-B2 | Parasiticidal compositions comprising indole derivatives, methods and uses thereof | MERIAL INC. (US) | 2017-10-03 | — | — | US | disclosed |
| US-9650375-B2 | Indole derivatives useful as anti-diabetic agents | MERCK SHARP & DOHME CORP. (US) | 2017-05-16 | — | — | US | disclosed |
| EP-3157912-A1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | Merial, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |
| US-20150366198-A1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | MERIAL, INC. (US) | 2015-12-24 | — | — | US | disclosed |
| US-20150366198-A1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | MERIAL, INC. (US) | 2015-12-24 | — | — | US | disclosed |
| US-20150366198-A1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | MERIAL, INC. (US) | 2015-12-24 | — | — | US | disclosed |
| WO-2015196014-A1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | MERIAL, INC. (US) | 2015-12-23 | — | — | WO | disclosed |
| WO-2015196014-A1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | MERIAL, INC. (US) | 2015-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10251863-B2 | Parasiticidal compositions comprising indole derivatives, methods and uses thereof | IDO1, IDO2, MMP1 | MEN1 2999/4885KMT2A 2805/4885USP2 2410/4885 |
| US-20170290803-A1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | IDO1, IDO2, MMP1 | MEN1 2999/4885KMT2A 2805/4885USP2 2410/4885 |
| US-20150366198-A1 | PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF | IDO1, IDO2, MMP1 | MEN1 2999/4885KMT2A 2805/4885USP2 2410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.