Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSB | P07858 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | GALR1 | P47211 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1735169 | 0.82 | ALDH1A1 (0.53) | CHEK1IKBKBALDH1A1SYKHDAC3 | |
| SCHEMBL1735224 | 0.77 | GRM5 (0.57) | IKBKBCHUKALDH1A1 | |
| SCHEMBL1734402 | 0.76 | GRM5 (0.55) | IKBKBCHUK | |
| SCHEMBL13605397 | 0.76 | FLT3 (0.49) | TYRO3AXLHRH3CHRM1ALDH1A1 | |
| SCHEMBL1735278 | 0.72 | HDAC3 (0.44) | TYRO3AXLCHEK1CTSLCTSB | |
| SCHEMBL1735254 | 0.72 | L3MBTL3 (0.52) | CHRM2CHRM1CHRM3 | |
| SCHEMBL10971409 | 0.72 | HDAC3 (0.59) | ALDH1A1SYKHDAC3HDAC1HDAC2 | |
| SCHEMBL1735187 | 0.71 | CCNC (0.63) | HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL1735164 | 0.71 | SYK (0.55) | TYRO3AXLIKBKBCHUKSYK | |
| SCHEMBL13605489 | 0.71 | GRM5 (0.67) | ALDH1A1HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928236-B1 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM LLC (BM) | 2011-11-23 | — | — | EP | disclosed |