Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 7/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 7/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 3/20 | 0.43 |
| ▸ | CCND1 | P24385 | 3/20 | 0.43 |
| ▸ | CCND2 | P30279 | 3/20 | 0.43 |
| ▸ | CCND3 | P30281 | 3/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | WEE1 | P30291 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1734235 | 0.89 | RIPK2 (0.43) | HRH3RIPK2NOD2ACVR1LCK | |
| SCHEMBL1734414 | 0.86 | CDK4 (0.47) | RIPK2NOD2ACVR1CDK4CCND1 | |
| SCHEMBL1735394 | 0.84 | RIPK2 (0.43) | HRH3RIPK2NOD2ACVR1LCK | |
| SCHEMBL1734211 | 0.84 | RARA (0.52) | HRH3RIPK2NOD2ACVR1LCK | |
| SCHEMBL1736459 | 0.81 | RIPK2 (0.48) | HRH3RIPK2NOD2ACVR1LCK | |
| SCHEMBL1736410 | 0.79 | RIPK2 (0.51) | HRH3RIPK2NOD2ACVR1CDK4 | |
| SCHEMBL1735289 | 0.78 | MCHR1 (0.50) | RIPK2NOD2ACVR1CDK4CCND1 | |
| SCHEMBL1735255 | 0.77 | CSNK2A1 (0.60) | HRH3RIPK2NOD2ACVR1CDK4 | |
| SCHEMBL1735178 | 0.77 | MCHR1 (0.52) | RIPK2NOD2ACVR1CDK4CCND1 | |
| SCHEMBL4462748 | 0.77 | HRH3 (0.49) | HRH3RIPK2NOD2ACVR1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928236-B1 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM LLC (BM) | 2011-11-23 | — | — | EP | disclosed |