SCHEMBL1735369

SCHEMBL1735369

Brc1ccc2c(c1)CCCN2Cc1ncc[nH]1.c1ccc(COc2cccc3c2CCCN3Cc2ncc[nH]2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK1 Q13464 1/20 0.42
HTR6 P50406 2/20 0.38
FNTA P49354 1/20 0.37
FNTB P49356 1/20 0.37
HDAC1 Q13547 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
ADRB3 P13945 2/20 0.36
ADRB2 P07550 1/20 0.36
ADRB1 P08588 1/20 0.36
RXRB P28702 3/20 0.36
RXRA P19793 2/20 0.36
MRGPRX4 Q96LA9 1/20 0.36
LMNA P02545 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
ALDH1A1 P00352 1/20 0.36
HTT P42858 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
NCOA3 Q9Y6Q9 1/20 0.35
PTGER1 P34995 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1734420 0.89 ROCK1 (0.50) ROCK1HTR6FNTAFNTBHDAC1
SCHEMBL1735456 0.82 HDAC1 (0.46) ROCK1FNTAFNTBHDAC1HDAC8
SCHEMBL3827595 0.77 FNTA (0.46) ROCK1FNTAFNTBHDAC1HDAC8
SCHEMBL1735415 0.77 HTR2C (0.40) ROCK1HTR6FNTAFNTBHDAC1
SCHEMBL1734450 0.76 ALOX15 (0.45) ROCK1FNTAFNTBHDAC1HDAC8
SCHEMBL1735386 0.75 HRH3 (0.45) ADRB3ADRB2ADRB1MRGPRX4L3MBTL1
SCHEMBL1736704 0.74 TAAR1 (0.56) FNTAFNTBHDAC1HDAC6LMNA
SCHEMBL12993166 0.71 TAAR1 (0.58) ROCK1HTR6FNTAFNTBLMNA
SCHEMBL3529731 0.70 ROCK1 (0.45) ROCK1HTR6HDAC1HDAC6RXRB
SCHEMBL1734486 0.70 ADRA2A (0.44) HTR6FNTAFNTBHDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2086959-B1 SUBSTITUTED 2-IMIDAZOLES AS MODULATORS OF THE TRACE AMINE ASSOCIATED RECEPTORS HOFFMANN LA ROCHE (CH) 2011-11-16 EP claimed
US-20110264029-A1 IONTOPHORETIC DELIVERY SYSTEM Kopman, Stanley E. (CA) 2011-10-27 US claimed
EP-2086959-A1 SUBSTITUTED 2-IMIDAZOLES AS MODULATORS OF THE TRACE AMINE ASSOCIATED RECEPTORS F.HOFFMANN-LA ROCHE AG (CH) 2009-08-12 EP claimed
WO-2008052907-A1 SUBSTITUTED 2-IMIDAZOLES AS MODULATORS OF THE TRACE AMINE ASSOCIATED RECEPTORS F. HOFFMANN-LA ROCHE AG (CH) 2008-05-08 WO claimed
EP-2086959-A1 SUBSTITUTED 2-IMIDAZOLES AS MODULATORS OF THE TRACE AMINE ASSOCIATED RECEPTORS F.HOFFMANN-LA ROCHE AG (CH) 2009-08-12 EP disclosed
WO-2008052907-A1 SUBSTITUTED 2-IMIDAZOLES AS MODULATORS OF THE TRACE AMINE ASSOCIATED RECEPTORS F. HOFFMANN-LA ROCHE AG (CH) 2008-05-08 WO disclosed