Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 7/20 | 0.38 |
| ▸ | DRD3 | P35462 | 7/20 | 0.38 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13638 | 0.94 | DRD2 (0.40) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL14011 | 0.93 | DRD2 (0.40) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL17354246 | 0.90 | BACE1 (0.39) | MAPTDRD2DRD3HTR1AHTR2A | |
| SCHEMBL17354251 | 0.89 | BACE1 (0.37) | MAPTDRD2DRD3HTR1AHTR2A | |
| SCHEMBL17354298 | 0.87 | DRD2 (0.41) | MAPTDRD2DRD3HTR1AHTR2A | |
| SCHEMBL17354254 | 0.87 | KMT2A (0.48) | MAPTDRD2DRD3HTR1AHTR2A | |
| SCHEMBL17354260 | 0.87 | CCR2 (0.38) | DRD2 | |
| SCHEMBL17354360 | 0.85 | KMT2A (0.52) | MAPTDRD2DRD3HTR1AHTR2A | |
| SCHEMBL13929 | 0.83 | BACE1 (0.41) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL14850245 | 0.83 | DRD2 (0.46) | DRD2DRD3HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216979-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-12-22 | — | — | US | disclosed |