Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.36 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17486576 | 0.94 | IGF1R (0.35) | IGF1RP2RY1HDAC1KMT2AMEN1 | |
| SCHEMBL17486581 | 0.94 | IGF1R (0.33) | IGF1RP2RY1 | |
| SCHEMBL17486543 | 0.93 | KMT2A (0.34) | IGF1RP2RY1HDAC1KMT2AMEN1 | |
| SCHEMBL17486575 | 0.93 | IGF1R (0.33) | IGF1RP2RY1 | |
| SCHEMBL17486553 | 0.92 | IGF1R (0.33) | IGF1RP2RY1ROCK2LIMK1 | |
| SCHEMBL17486568 | 0.92 | HDAC1 (0.36) | IGF1RP2RY1HDAC1KMT2AMEN1 | |
| SCHEMBL13589 | 0.90 | KDR (0.40) | IGF1RP2RY1HDAC1 | |
| SCHEMBL17486554 | 0.89 | P2RY1 (0.35) | IGF1RP2RY1MAPT | |
| SCHEMBL13975 | 0.88 | KDR (0.38) | IGF1RP2RY1HDAC1 | |
| SCHEMBL13963 | 0.87 | KDR (0.38) | IGF1RP2RY1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216979-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-12-22 | — | — | US | disclosed |