Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.78 |
| ▸ | MEN1 | O00255 | 5/20 | 0.78 |
| ▸ | POLB | P06746 | 4/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.78 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 3/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5978453 | 0.82 | MEN1 (0.79) | KMT2AALDH1A1MEN1POLBKDM4E | |
| SCHEMBL2624630 | 0.81 | KMT2A (0.74) | KMT2AALDH1A1MEN1POLBKDM4E | |
| SCHEMBL6673184 | 0.80 | ALDH1A1 (0.76) | KMT2AALDH1A1MEN1POLBKDM4E | |
| SCHEMBL19659988 | 0.79 | MEN1 (0.74) | KMT2AALDH1A1MEN1POLBKDM4E | |
| SCHEMBL27829159 | 0.79 | ALDH1A1 (0.82) | KMT2AALDH1A1MEN1POLBKDM4E | |
| SCHEMBL914359 | 0.78 | NPC1 (0.71) | KMT2AALDH1A1MEN1KDM4ESMN1; SMN2 | |
| SCHEMBL8016999 | 0.78 | ALDH1A1 (0.73) | KMT2AALDH1A1MEN1POLBKDM4E | |
| SCHEMBL692806 | 0.76 | ALDH1A1 (0.76) | KMT2AALDH1A1MEN1POLBKDM4E | |
| SCHEMBL29444198 | 0.76 | ALDH1A1 (0.76) | KMT2AALDH1A1MEN1POLBKDM4E | |
| SCHEMBL10833831 | 0.75 | KMT2A (0.65) | KMT2AALDH1A1MEN1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9216180-B2 | Pharmaceutical compositions and treatment of genetic diseases associated with nonsense mediated RNA decay | NEW YORK UNIVERSITY (US) | 2015-12-22 | — | — | US | disclosed |